Peptide Elongation Factor Tu

A protein found in bacteria and eukaryotic mitochondria which delivers aminoacyl-tRNA's to the A site of the ribosome. The aminoacyl-tRNA is first bound to a complex of elongation factor Tu containing a molecule of bound GTP. The resulting complex is then bound to the 70S initiation complex. Simultaneously the GTP is hydrolyzed and a Tu-GDP complex is released from the 70S ribosome. The Tu-GTP complex is regenerated from the Tu-GDP complex by the Ts elongation factor and GTP.

Also Known As:

EF-Tu; Eucaryotic Elongation Factor Tu; Protein Synthesis Elongation Factor Tu; eEF-Tu; EF Tu; Factor Tu, Elongation; eEF Tu; Elongation Factor Tu

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - GTP Phosphohydrolases: 2307
        GTP-Binding Proteins: 5624
        GTP Phosphohydrolase-Linked Elongation Factors
        Peptide Elongation Factor Tu: 90
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - GTP-Binding Proteins: 5624
      - GTP Phosphohydrolase-Linked Elongation Factors
        Peptide Elongation Factor Tu: 90
  - Ribosomal Proteins: 1138
    - Peptide Elongation Factors: 297
      - GTP Phosphohydrolase-Linked Elongation Factors
        Peptide Elongation Factor Tu: 90
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Proteins: 5624
      - GTP Phosphohydrolase-Linked Elongation Factors
        Peptide Elongation Factor Tu: 90

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Disease

Drug/Important Bio-Agent (IBA)